What is the resorption rate?Steve2018-06-06T15:28:04-07:00poly(2,3)Glucose™ is stable in PBS at 25^o C. Slow degradation of molecular weight occurs in PBS at 37^o C. in vivo resorption of poly(2,3)Glucose™ depots occurs in mice . The resorption rate of depots depends on the difference between body and gel temperatures, and the polymer solution concentration. Gel temperature also influences the residence time in the needle used for depot injection and the spreading the depot prior to curing. This table compares the gels

Polymer ID	Gel Temp, o C	Resorption Time	Needle Residence	Spreading Resistance
T1-25	25	Longest	Shortest	Greatest
T1-30	30	Medium	Medium	Medium
T1-35	35	Shortest	Longest	Least

Which gel is right for my application?Steve2018-06-07T09:33:46-07:00Select your gel for it's gel temperature. The gels T1-25, T1-30, and T1-35 have nominal gel transition temperatures (lower critical solution temperatures) of 25, 30, and 35^o C. The actual gel temperature will vary with polymer concentration and with the concentration of salts. The temperature responsive gel page gives guidance on these variations. The extent of phase change increases with the difference between ambient and gel temperatures. For example, T1-25 is recommended for cell encapsulation because it has the greatest temperature difference at body temperature of the three gels making the firmest gel capsule. At room temperature, is has the smallest temperature difference, which affords the greatest handling time before the gel dissolves. T1-30 is recommended for injectable depots because it's gel temperature provides rapid depot formation at 37^o C while keeping the needle flowing. T1-35 is best for tumorigenicity assays because it makes a low modulus, soft agar substitute at 37^o C and it quickly dissolves at 4^o C to recover transformed cells. Properties relevant to application of poly(2,3)Glucose™ gels are summarized in this table.