Biocompatible
hydrophillic and non-toxic like PEO

poly(2-3)Glucose™ is a polyether, chemically similar to polyethylene oxide (PEO.)  The poly(2-3)Glucose™ heteropolymers T1-25, T1-30, and T1-35 are hydrophilic, charge neutral, hydrogen bond acceptors, but not donors.  These biocompatible characteristics corroborate the below data, which demonstrates compatibility with human islet cells, human lymphoblasts, murine macrophages,  and murine adipose tissue.

The polymer is provided as a lyophilized cake in a serum vial. It is sterile, non-pyrogenic, non-toxic, and hydrophilic. To make a solution, add sterile PBS or growth media via the butyl septa and chill overnight at 4 C.

poly(2-3)Glucose™ compatible with human islets

Human islets encapsulated for cell therapy
Human Islets of Langerhans encapsulated in polymer T1-25.
Human islet stimulated insulin release for naked and poly (2-3) glucose encapsulated islets.
Angiogenesis in murine abdominal cavity containing human islets encapsulated with poly (2-3) glucose.

poly(2-3)Glucose non-toxic with human lymphoblasts

Human Lymphoblastoid tk6 MTS assay

poly(2-3)Glucose non-inflammatory with murine macrophages

poly(2,3)Glucose not inflammatory to murine macrophage j774
Murine Macrophage j774, Interleukin-6 assay

No inflammation in mouse

Surgical resection of gel depots ten days after injection. The formulation on the left resorbs more rapidly than the formulation of the right.

Normal mouse tissue histology

Histology adjacent to biocompatible depot
A poly(2,3)Glucose depot was injected subcutaneously (SQ) into a mouse. Adjacent tissue was sampled 3 days later.