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Temperature Responsive Gel
poly(2,3)GlucoseTM
- Liquid below Tgel and solid above Tgel
- Biocompatible
- Sterile
- Stays gel while handling at room temperature
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Tumorigenicity Assay
Transformed melanoma cell colonies expanding in poly(2-3)GlucoseTM gel.
- poly(2-3)GlucoseTM solution is a liquid at 25 oC
- Suspend cells in 5 wt% T1-35 solution
- Pour into wells at 25 oC
- T1-35 solution is a solid gel at 35 oC
- Incubate at 37 oC
- Grow cells to transformation
- Recover metastases at 4 oC
Temperature-responsive gel quicker than soft agar
more info... -
Injectable Depot
poly(2-3)GlucoseTM gel depot at 7 days
Temperature-responsive gel more biocompatible than PLGA
- poly(2-3)GlucoseTM solution is a liquid at 25 oC
- Suspend therapeutic in 10 wt% T1-30 solution
- Inject at 25 oC
- T1-30 solution is a solid gel at 30 oC
- Depot forms instantly at 37 oC
- Localized therapeutic slowly releases
- Depot bioresorbs without forming R-COOH
more info... - Cell Encapsulation and Cell TherapyIslets of Langerhans encapsulated in poly(2-3)GlucoseTM gel.
- poly(2-3)GlucoseTM solution is a liquid at 25 oC
- Suspend cells in 15 wt% T1-25 at 25 oC
- Form capsules in oil
- T1-25 solution is a solid gel at 27 oC
- Gel and separate at 37 oC
- Implant encapsulated xenogenic cells
- Cure diabetes in mouse model
Temperature-responsive gel more stable than Ca-alginatemore info...
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